Shanghai JIAI Genetics & IVF Institute
Shanghai JIAI Genetics & IVF Institute: Precision Genetic Diagnosis · Customized Assisted Reproduction · Full-Cycle Fertility Health Management
Shanghai JIAI Genetics & IVF Institute is a specialized, research-oriented institution for assisted reproduction and genetic disease diagnosis and treatment, approved by the Shanghai Municipal Health Commission. It focuses on providing comprehensive services spanning the entire chain of “genetic disease screening - assisted reproduction - eugenics and childbirth.” Leveraging China's top reproductive medicine teams and genetic experts alongside cutting-edge international technologies (such as PGT for third-generation IVF and whole-genome sequencing), the institute is committed to providing one-stop solutions encompassing “precision diagnosis, personalized treatment, and comprehensive health management” for infertile families, couples at high risk for genetic disorders, and individuals with specialized fertility needs.
Located in Shanghai's Pudong International Medical Park (core medical zone), the institute spans approximately 30,000 square meters. It features JCI-accredited embryo laboratories, genetic testing centers, and VIP treatment areas, completing over 5,000 assisted reproductive cycles annually. Its genetic disease screening and diagnostic volume ranks among the top in the Yangtze River Delta region. As one of China's few specialized institutions combining “precision genetic disease diagnosis and treatment” with “high-success-rate assisted reproduction,” it offers dual expertise.
I. Hospital Profile: A Research-Focused Specialty Institution Dedicated to “Genetics + Reproduction”
Established in 2015, Shanghai JIAI Genetics & IVF Institute was founded under the leadership of pioneers in China's reproductive medicine field. It brings together genetics and embryology experts from institutions including the Obstetrics and Gynecology Hospital of Fudan University and Shanghai Jiao Tong University School of Medicine. Distinct from traditional assisted reproductive institutions, Shanghai JIAI Genetics & IVF Institute centers on “genetic disease prevention and control” as its core specialty. It has established a three-pronged development model integrating “clinical diagnosis and treatment, basic research, and technology transfer”:
• Clinical Services: Specialized departments for infertility diagnosis and treatment, genetic counseling, assisted reproduction (IVF), prenatal diagnosis, and recurrent miscarriage management, covering the entire fertility journey from preconception assessment to postpartum care.
• Research: Focuses on optimizing preimplantation genetic testing (PGT) technology, gene editing for rare genetic disorders, and developmental regulation mechanisms of gametes/embryos. Collaborates with universities to establish the “Joint Reproductive Genetics Laboratory,” publishing over 80 SCI papers and securing 15 national invention patents in the past five years.
• Service Platform: Tailored services for international families, high-net-worth individuals, and high-risk genetic families, including personalized genetic counseling, multidisciplinary team (MDT) consultations, and direct billing to international insurance providers, delivering compassionate yet professional medical care.
II. Technical Advantages: Dual-Drive Approach of Precision Genetic Diagnosis + Assisted Reproductive Innovation
Shanghai JIAI Genetics & IVF Institute leverages “genetics empowering reproductive medicine” as its core competency, establishing significant strengths in Assisted Reproductive Technology (ART) and genetic disease prevention:
1. Assisted Reproductive Technology: Balancing High Success Rates with Personalized Solutions
• Third-Generation IVF (PGT) Technology: As one of China's first institutions certified for Preimplantation Genetic Testing (PGT), JIAI offers PGT-A (chromosomal number screening), PGT-M (single-gene disorder prevention), and PGT-SR (structural chromosomal abnormality correction). These cover over 300 single-gene disorders (e.g., thalassemia, spinal muscular atrophy [SMA], cystic fibrosis), with embryo screening accuracy exceeding 99% and clinical pregnancy rates consistently above 65% (exceeding industry averages).
• Blastocyst Culture and Vitrification Technology: The embryo lab is equipped with a Time-lapse embryo monitoring system (dynamically records the entire embryo development process), laser hatching devices (precisely assist embryo hatching), and cryogenic freezing equipment (a cluster of -196°C liquid nitrogen tanks). Blastocyst formation rates reach 70%, with cryopreservation survival rates exceeding 98%. We support personalized treatment plans, including “full embryo cryopreservation” and “staged embryo transfer.”
• Microsurgical Treatment for Male Infertility: We employ techniques including Microsurgical Testicular Sperm Extraction (Micro-TESE) and Microsurgical Varicocelectomy. For patients with azoospermia or severe oligoasthenozoospermia, our sperm retrieval success rate reaches 85%. Combined with ICSI (Intracytoplasmic Sperm Injection) technology, we achieve breakthroughs in fertility outcomes.
2. Genetic Disease Prevention: Comprehensive Solutions from Screening to Interception
• Comprehensive Prenatal Genetic Risk Assessment: Enables early detection and intervention through preconception screening (covering over 300 recessive genetic disorders), early pregnancy non-invasive prenatal testing (NIPT-plus), and mid-pregnancy amniocentesis combined with whole-exome sequencing (WES).
• Precision Diagnosis of Rare Diseases: In collaboration with Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine and the International Center for Pediatric Genetic Diseases, we established a “Rare Disease Gene Database” capable of diagnosing over 2,000 rare genetic disorders (e.g., phenylketonuria, Duchenne muscular dystrophy (DMD), spinocerebellar ataxia) with over 95% diagnostic accuracy.
• Exploring Gamete/Embryo Genetic Modification: Participating in the National Key R&D Program “Development of New Technologies for Preimplantation Genetic Diagnosis,” exploring CRISPR-Cas9-based embryo gene repair (within research ethics boundaries) to offer “root-cause treatment” possibilities for patients with single-gene hereditary diseases.
III. Leading Specialties: Focusing on Core Needs, Setting Specialty Benchmarks
Centered on the “genetics + reproduction” axis, the institute has established a specialized system covering “assessment-treatment-prevention”:
• Genetic Counseling Department: Led by a team of National Health Commission-certified genetic counselors, it provides preconception/prenatal genetic risk assessment, analysis of familial genetic histories, and guidance on PGT applicability, handling over 8,000 consultations annually.
• Assisted Reproductive Technology Department (IVF Center): Offers first-generation (IVF), second-generation (ICSI), and third-generation (PGT) IVF technologies. Develops personalized treatment plans for complex cases, including advanced maternal age (≥38 years), recurrent implantation failure (RIF), and endometriosis. Maintains Shanghai's top clinical pregnancy rates for three consecutive years.
• Prenatal Diagnosis Center: Equipped with high-throughput gene sequencers (Illumina NovaSeq 6000) and chromosomal microarray analysis (CMA) devices, the center provides invasive diagnostic services including amniocentesis, chorionic villus sampling, and cordocentesis. It also offers non-invasive testing such as non-invasive prenatal testing (NIPT) and fetal cardiac ultrasound screening.
• Infertility Diagnosis and Treatment Department: Addresses causes including ovulatory disorders (e.g., polycystic ovary syndrome, PCOS), tubal factors, and immune infertility. Comprehensive solutions include ovulation induction therapy, combined hysteroscopic and laparoscopic surgery, and integrated Chinese and Western medicine regulation. Ovulation induction cycle success rate exceeds 70%.
• Recurrent Miscarriage Center: We have established a four-dimensional diagnostic and treatment system encompassing “thrombophilia screening, endocrine regulation, immune abnormality intervention, and intrauterine environment optimization.” This approach achieves a pregnancy preservation success rate exceeding 80% for patients experiencing recurrent spontaneous miscarriages (≥2 occurrences).
IV. Departments and Medical Equipment: Precision Configuration Supporting Cutting-Edge Technology
The institute's departments are highly specialized, with world-class equipment configured around three core processes: genetic testing, embryo culture, and clinical diagnosis and treatment.
1. Core Departments
• Genetic Counseling Department, Assisted Reproductive Medicine Department (IVF Center), Prenatal Diagnosis Center, Infertility Diagnosis and Treatment Department, Recurrent Miscarriage Diagnosis and Treatment Center, Andrology Department (including Microsurgical Andrology), Embryology Laboratory, Genetic Testing Center (co-established with a third-party medical testing institute).
2. Key Medical Equipment
• Genetic Testing Equipment: Illumina NovaSeq 6000 (Whole Genome Sequencing), Affymetrix CytoScan (Chromosomal Microarray Analysis), Digital PCR System (Precision Quantification for Monogenic Disorders).
• Embryology Laboratory Equipment: EmbryoScope Plus (real-time embryo monitoring system), Laser Hatching Device (assisted embryo hatching), MVE Liquid Nitrogen Tank (ultra-low temperature embryo cryopreservation), Narishige Micromanipulation System (Intracytoplasmic Sperm Injection).
• Clinical Diagnostic Equipment: High-end transvaginal ultrasound (GE Voluson E10, supporting endometrial receptivity assessment), hysteroscope (Olympus OTV-S7, precise diagnosis of intrauterine adhesions), fully automated chemiluminescent immunoassay analyzer (for sex hormone and anti-Müllerian hormone AMH testing).
V. International Patient Services: Bridging Language and Culture in Fertility Care
As a designated Shanghai “International Medical Tourism Pilot Unit,” Shanghai JIAI Genetics & IVF Institute delivers comprehensive, borderless fertility services tailored for international families, overseas returnees, and cross-border healthcare seekers:
• Multilingual Support: Our International Medical Center (IMC) features professional translators fluent in English, Japanese, Korean, French, and Spanish. Medical staff undergo cross-cultural communication training. All test reports and informed consent forms are provided in bilingual Chinese-English versions, with religious customs accommodated (e.g., halal meals, prayer rooms).
• Streamlined Appointment Process: International patients may book appointments via the official website, WeChat Official Account (Shanghai JIAI Genetics & IVF Institute), or dedicated customer service (400-900-8822). Online medical history submission and test report uploads are supported (English reports can be directly translated). Bilingual patient navigators accompany patients throughout visits, eliminating queuing and waiting times.
• Direct Billing with International Insurers: Contracts with global insurers, including MSH (Métropole Santé), Cigna, Aetna, and BUPA, cover assisted reproductive technologies (select services), genetic testing, prenatal diagnosis, and more. Direct settlement eliminates upfront payment requirements.
• Cross-Border Medical Coordination: Offers an “International Referral Green Channel” to connect foreign patients with overseas specialists for remote consultations (e.g., Stanford University Fertility Center, University of Cambridge Genetics Department). Provides recommendations for Shanghai international community apartments, international schools, and other supporting resources for families requiring long-term treatment.
VI. International Patient Testimonials: “Fertility Hope Where Science Meets Compassion”
In recent years, Shanghai JIAI Genetics & IVF Institute has helped nearly a thousand families from over 20 countries—including the United States, the United Kingdom, Japan, Australia, and Singapore—fulfill their dreams of parenthood, garnering numerous genuine testimonials:
• “As a same-sex couple from the U.S. unable to conceive naturally, we chose JIAI. The genetic counseling team thoroughly explained the genetic matching protocols for egg/sperm donation. The embryo lab screened embryos using cutting-edge PGT technology, leading to a successful transfer and healthy birth. The doctors here are not only highly professional but also genuinely empathetic—they understood our needs like friends!” — Emily & Rachel, U.S. patients.
• “As carriers of spinal muscular atrophy (SMA) diagnosed in Japan, my husband and I hesitated to have children due to genetic concerns. Jia'ai's genetics team confirmed my carrier status through WES testing and selected healthy embryos using PGT-M technology. Now my daughter is 2 years old and perfectly healthy! Thank you, Jia'ai, for giving us a complete family.” — — Japanese patient Misaki Sato.
• “After two failed IVF attempts in Australia, I came to Jia'ai with my last hope. The doctors analyzed my embryo development data, adjusted my stimulation protocol, and used Time-lapse technology to monitor embryo quality in real-time. My third transfer was successful! The embryo lab equipment here is more advanced than anything I saw in Australia. Thank you for making my dream of becoming a mother come true.” — — Australian patient Liam.
VII. Contact Information & Transportation Guide
• Address: No. 4399 Kangxin Highway, Pudong New Area, Shanghai (Within Shanghai International Medical Park, near Zhou-Deng Highway)
• Consultation Hotline: 400-900-8822 (Main Switchboard); 021-5089-8822 (International Medical Department)
• WeChat Official Account: Shanghai JIAI Genetics & IVF Institute (Supports report inquiries, online consultations, and international insurance direct payment guidance)
• Transportation Routes:
• Subway: Exit 3 at Zhoupu East Station (Line 16), transfer to Pudong Bus Route 58 to Kangxin Highway/Zhudeng Highway Station. 5-minute walk.
• By Car: Navigate to “Shanghai JIAI Genetics & IVF Institute.” Underground parking available (first 2 hours free).
• By Bus: Take Pudong Bus Route 4 or Pudong Bus Route 25 to “Kangxin Highway/Zhou-Deng Highway Station,” then walk 3 minutes.
Since its founding in 2015, Shanghai JIAI Genetics & IVF Institute has upheld its mission: “Safeguarding life's beginning through science, delivering hope for parenthood with compassion.” By seamlessly integrating the precision of genetics with the human touch of assisted reproduction, we ignite hope for every family aspiring to parenthood. Whether for families facing genetic disease risks or couples seeking efficient fertility solutions, this institute stands as a trusted guardian of fertility.
Document dated 2025-09-15 10:44 Modify